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CD4 T-cell depletion and chronic inflammation are the two signature events that drive HIV pathogenesis and progression to AIDS. Infection of the cells of the CNS cause acute aseptic meningitis, subacute encephalitis, vacuolar myelopathy and peripheral neuropathy. Later it leads to even AIDS dementia complex.
Immune reconstitution inflammatory syndrome (IRIS) is a condition seen in some cases of HIV/AIDS or immunosuppression, in which the immune system begins to recover, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse.
When the HIV infection becomes life-threatening, it is called AIDS. People with AIDS fall prey to opportunistic infections and die as a result. [60] When the disease was first discovered in the 1980s, those who had AIDS were not likely to live longer than a few years. There are now antiretroviral drugs (ARVs) available to treat HIV infections.
Health Sciences Online (HSO) is a non-profit online health information resource that launched in December 2008. The website hosts a virtual learning center providing weblinks to a collection of more than 50,000 courses, references, textbooks, guidelines, lectures, presentations, cases, articles, images and videos, available in 42 different languages.
The management of HIV/AIDS typically involves the use of multiple antiretroviral drugs. In many parts of the world, HIV has become a chronic condition, with progression to AIDS increasingly rare. HIV latency and the resulting viral reservoir in CD4 + T cells, dendritic cells, and macrophages is the main barrier to eradication of the virus. [19 ...
In 2016, about 36.7 million people were living with HIV, and it resulted in 1 million deaths. [11] There were 300,000 fewer new HIV cases in 2016 than in 2015. [12] Most of those infected, live in sub-Saharan Africa. [4]
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