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The Ervebo vaccine, developed by Merck, is a single-dose vaccine. It works by using a modified virus to produce antibodies against Ebola, equipping the immune system to recognise and neutralise ...
There is also a version called GamEvac which is a homologous Ad5-vectored vaccine. [1] GamEvac-Combi was developed by Gamaleya Research Institute of Epidemiology and Microbiology . As of 2015 [update] the vaccine has been licensed in Russia for emergency use, on the basis of Phase 1 and Phase 2 clinical trials.
Ebola vaccines are vaccines either approved or in development to prevent Ebola. As of 2022, there are only vaccines against the Zaire ebolavirus. The first vaccine to be approved in the United States was rVSV-ZEBOV in December 2019. [9] [10] It had been used extensively in the Kivu Ebola epidemic under a compassionate use protocol. [11]
Up to an additional US$90 million could be used to support countries to introduce the vaccines and to rebuild and restore immunisation services for all vaccines in Ebola-affected countries. [ 186 ] In December 2016, it was announced that an experimental Ebola vaccine produced by Merck was found to be "highly protective" against the virus after ...
A stockpile of half-a-million Ebola vaccine doses was established by Gavi and other global health partners in 2019 for use in outbreaks of haemorrhagic fever, which has an average fatality rate of ...
In April 2019, following a large-scale ring-vaccination scheme in the DRC outbreak, the WHO published the preliminary results of its research, in association with the DRC's Institut National pour la Recherche Biomedicale, into the effectiveness of the ring vaccination program, stating that the rVSV-ZEBOV-GP vaccine had been 97.5% effective at stopping Ebola transmission, relative to no ...
The 2014 Ebola outbreak – the deadliest in history – was primarily in West Africa but affected Sierra Leone the most, with nearly 4,000 deaths out of the more than 11,000 recorded globally. The country also lost 7% of its healthcare workforce to the outbreak.
“Disease X,” according to the World Health Organization, “represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human ...