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Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [ 1 ] [ 2 ] It is used together with a diabetic diet and exercise.
Lower risk of gastrointestinal side effects than metformin; Convenient dosing; Cause an average of 2–5 kg weight gain; Increase the risk of hypoglycemia; Glyburide increases risk of hypoglycemia slightly more compared to glimepiride and glipizide; Metformin
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
Read More: Patients Are Suing Over Alleged Side Effects of Weight-Loss Drugs. The group found that people taking the GLP-1 medications had a lower risk of a number of health conditions, including ...
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now. GLP-1s ...
Frequently reported side effects include: nausea, heartburn, weight gain, and bloating. [8] The medication is also a major cause of medication-induced hypoglycemia . The risk is greater than with other sulfonylureas .
Evidence suggests weight loss drugs can also suppress inflammation. However, they don’t work for everyone, and can come with serious side effects. Weight loss drugs offer heart healthy benefits ...