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Nogapendekin alfa inbakicept, sold under the brand name Anktiva, is a fixed-dose combination medication used for the treatment of bladder cancer. [1] It is an interleukin-15 receptor agonist. [1] It is given in combination with Bacillus Calmette-Guérin via intravesical drug delivery. [1]
Several cancer vaccines use BCG as an additive to provide an initial stimulation of the person's immune system. [citation needed] BCG is used in the treatment of superficial forms of bladder cancer. Since the late 1970s, evidence has become available that the instillation of BCG into the bladder is an effective form of immunotherapy in this ...
The safety and effectiveness of nadofaragene firadenovec was evaluated in a multicenter clinical study (Study CS-003 (NCT02773849)) that included 157 participants with high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer, 98 of whom had BCG-unresponsive carcinoma in situ with or without papillary tumors and could be evaluated for response.
This is seen in about 75-85% patients of bladder cancer, the company said. Bladder cancer patients currently have to undergo a procedure called surgical ablation and either get chemotherapy or BCG ...
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In 1990, the treatment became the first therapy approved for use by the FDA against solid NMIBC tumors [10] [11] and remains the "gold standard" treatment more than 40 years later. [12] In 2018, BCG was described in the Canadian Urological Association Journal as "the most effective, and longest continually used immunotherapy for any cancer." [13]
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