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16846 Ensembl ENSG00000174697 ENSMUSG00000059201 UniProt P41159 P41160 RefSeq (mRNA) NM_000230 NM_008493 RefSeq (protein) NP_000221 NP_032519 Location (UCSC) Chr 7: 128.24 – 128.26 Mb Chr 6: 29.06 – 29.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Leptin Structure of the obese protein leptin-E100 Identifiers Symbol Leptin Pfam PF02024 Pfam clan CL0053 InterPro ...
Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, [5] a protein that in humans is encoded by the LEPR gene. [ 6 ] [ 7 ] LEP-R functions as a receptor for the fat cell-specific hormone leptin .
Leptin, a hormone secreted exclusively by adipose cells in response to an increase in body fat mass, is an important component in the regulation of long term hunger and food intake. Leptin serves as the brain's indicator of the body's total energy stores. When leptin levels rise in the bloodstream they bind to receptors in ARC. The functions of ...
The first adipokine to be discovered was leptin in 1994. [2] Since that time, hundreds of adipokines have been discovered. [3] Members include: Leptin; Adiponectin; Apelin [4] chemerin [5] interleukin-6 (IL-6) [6] monocyte chemotactic protein-1 (MCP-1) [7] plasminogen activator inhibitor-1 (PAI-1) retinol binding protein 4 (RBP4) tumor necrosis ...
The mesolimbic pathway transmits dopamine from the ventral tegmental area (VTA), which is located in the midbrain, to the ventral striatum, which includes both the nucleus accumbens and olfactory tubercle. [5] [6] The "meso" prefix in the word "mesolimbic" refers to the midbrain, or "middle brain", since "meso" means "middle" in Greek.
11604 Ensembl ENSG00000159723 ENSMUSG00000005705 UniProt O00253 P56473 RefSeq (mRNA) NM_001138 NM_001271806 NM_007427 RefSeq (protein) NP_001129 NP_001258735 NP_031453 Location (UCSC) Chr 16: 67.48 – 67.48 Mb Chr 8: 106.29 – 106.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the ...
The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain. [1] Its various components support a variety of functions including emotion, behavior, long-term memory, and olfaction. [2]
Douglas L. Coleman (October 6, 1931 - April 16, 2014) was a scientist and professor emeritus at the Jackson Laboratory, in Bar Harbor, Maine.His work predicted that there exists a hormone that can cause mice to feel full, and that a mutation in the gene encoding this hormone can lead to obesity. [3]