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Treatment may include dietary changes and folic acid supplements. [1] Dietary changes including eating foods high in folate such as, fruits and green leafy vegetables can help. [1] Prevention is recommended for pregnant women or those who are planning a pregnancy. [1] Folate deficiency is very rare in countries with folic acid fortification ...
Folate, also known as vitamin B 9 and folacin, [6] is one of the B vitamins. [3] Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. [7]
L-Methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml). [3]
The recommendation to start folic acid before conception is supported by a meta-analysis of 41 studies, but is beneficial after conception as well. [ 2 ] Often prenatal vitamins also have a reduced dosage of vitamins that may be detrimental to the fetus when taken in high doses (such as vitamin A ).
In common forms of MTHFR deficiency, elevated plasma homocysteine levels have sometimes been treated with Vitamin B12 and low doses of folic acid. [2] Although this treatment significantly decreases the serum levels of homocysteine, this treatment is not thought to improve health outcomes. [11] [12] [13]
Folic acid and food folates are absorbed and metabolized by different pathways. After digestion, food folates are converted in the small intestine to 5-methyltetrahydrofolic acid, a biologically active vitamer of vitamin B 9. Folic acid is absorbed and transported in the bloodstream to the liver, where it is converted to tetrahydrofolate, a ...
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