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Inclusion body myositis (IBM) (/ m aɪ oʊ ˈ s aɪ t ɪ s /) (sometimes called sporadic inclusion body myositis, sIBM) is the most common inflammatory muscle disease in older adults. [2] The disease is characterized by slowly progressive weakness and wasting of both proximal muscles (located on or close to the torso ) and distal muscles (close ...
There have been few randomized treatment trials, due to the relative rarity of inflammatory myopathies. [4] The goal of treatment is improvement in activities of daily living and muscle strength. Suppression of immune system activity (immunosuppression) is the treatment strategy. Patients with PM or DM almost always improve to some degree in ...
Polymyositis and the associated inflammatory myopathies have an associated increased risk of cancer. [3] The features they found associated with an increased risk of cancer were older age, age greater than 45, male sex, difficulty swallowing, death of skin cells, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase, higher erythrocyte sedimentation rate and higher ...
For myositis caused by a bacterial infection, antibiotics can be used. [4] For myositis caused by a medication, it is important to stop using that medication. [4] There are a variety of treatment options available if myositis is caused by an autoimmune disease. Glucocorticoids are often the first choice for treatment. [10]
People with MCTD typically have mild myositis, with normal muscle enzymes and electromyographic results. In fact, some people may be completely asymptomatic. Myositis can be severe and difficult to differentiate from conventional dermatomyositis. [10] Myalgia is a prevalent complaint among patients with MCTD. [33]
People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome. Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD and Antisynthetase syndrome .
Most people improve with treatment and in some, the condition resolves completely. [1] About one in 100,000 people receive a new diagnosis of dermatomyositis each year. [2] The condition usually occurs in those in their 40s and 50s with women being affected more often than men. [2] People of any age, however, may be affected. [2]
Generally, they are neuromuscular disorders characterized by muscle weakness developing in young adults. Hereditary inclusion body myopathies comprise both autosomal recessive and autosomal dominant muscle disorders that have a variable expression ( phenotype ) in individuals, but all share similar structural features in the muscles.