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Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.
In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17]
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
The maker of Robitussin settled a consumer lawsuit that claimed its "non-drowsy" cough and flu medicine causes drowsiness, agreeing to pay $4.5 million and remove the "non-drowsy" claim from its ...
No over-the-counter cough medicines have been found to be effective in cases of pneumonia. [9] They are not recommended in those who have COPD, chronic bronchitis, or the common cold. [10] [2] There is not enough evidence to make recommendations for those who have a cough in cancer. [11]
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
Early 20th century "Frog In Your Throat" box, containing lozenges made of cubeb, tolu balsam, liquorice, white horehound and wild cherry extracts.. Candies to soothe the throat date back to 1000 BC in Egypt's Twentieth Dynasty, when they were made from honey flavored with citrus, herbs, and spices.
The dose of bupropion in the study was lower than the target dose recommended for clinical practice. [10] In this study, dextromethorphan/bupropion showed significantly greater improvement than bupropion alone in the first two weeks of treatment but not by week 6 of treatment in people with major depressive disorder.