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Transverse section of head of chick embryo of forty-eight hours’ incubation Transverse section of head of chick embryo of fifty-two hours’ incubation, showing the lens and the optic cup. Eye formation in the human embryo begins at approximately three weeks into embryonic development and continues through the tenth week. [1]
During embryonic development of the eye, the outer wall of the bulb of the optic vesicles becomes thickened and invaginated, and the bulb is thus converted into a cup, the optic cup (or ophthalmic cup), consisting of two strata of cells.
Human embryonic development covers the first eight weeks of development, which have 23 stages, called Carnegie stages. At the beginning of the ninth week, the embryo is termed a fetus (spelled "foetus" in British English). In comparison to the embryo, the fetus has more recognizable external features and a more complete set of developing organs.
The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.
The ectoderm generates the outer layer of the embryo, and it forms from the embryo's epiblast. [13] The ectoderm develops into the surface ectoderm, neural crest, and the neural tube. [14] The surface ectoderm develops into: epidermis, hair, nails, lens of the eye, sebaceous glands, cornea, tooth enamel, the epithelium of the mouth and nose.
The puzzle of how embryonic development was controlled began to be solved using the fruit fly Drosophila melanogaster as a model organism. The step-by-step control of its embryogenesis was visualized by attaching fluorescent dyes of different colours to specific types of protein made by genes expressed in the embryo. [ 9 ]