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Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon. [1] [2] [3] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid). [2] It is prescribed for the treatment of pink eye in combination with ...
It is a combination of loteprednol, as the etabonate, a corticosteroid; and tobramycin, an aminoglycoside antibiotic. [1] It is used as drops in the eye. [1]
Tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations both have low systemic absorption. The formulation for injection is branded Nebcin.
A study with patients receiving loteprednol eye drops over 42 days showed no adrenal suppression, which would be a sign of the drug reaching the bloodstream to a clinically relevant extent. [2] Steroid receptor affinity was 4.3 times that of dexamethasone in animal studies. [2]
Ciprodex ear drops containing ciprofloxacin and dexamethasone [20] Ciproxin HC ear drops containing ciprofloxacin and hydrocortisone; Kenacomb ear drops, containing triamcinolone acetonide, neomycin and gramicidin (antibiotics) and nystatin [21] Sofradex ear drops containing neomycin and gramicidin (antibiotics) plus dexamethasone (a steroid) [22]
The Detroit Lions laid down a marker for their season with a statement victory over the Green Bay Packers on Thursday evening.. Lions running back David Montgomery ran for 121 yards and three ...