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Roth's spots, also known as Litten spots or the Litten sign, [1] are non-specific red lesions with white or pale centres, seen on the retina of the eye and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV.
Litten's sign is a clinical sign in which cotton wool spots are seen on fundoscopic examination of the retina in patients with infective endocarditis. [ 1 ] The sign is named after Moritz Litten .
Immunologic phenomena: glomerulonephritis which allows for blood and albumin to enter the urine, [12] Osler's nodes ("ephemeral spots of a painful nodular erythema, chiefly in the skin of the hands and feet"), Roth's spots on the retina, positive serum rheumatoid factor; Other signs may include night sweats, rigors, anemia, spleen enlargement [22]
If your whole eye has gone red, learn about the causes of bloodshot eyes and how to fix them. Weirdly enough, a red spot on eye might have a cause totally unrelated to your eyes: sneezing or coughing.
A major cause of Bitot's spots is vitamin A deficiency (VAD). [4] Rarely, pellagra due to deficiency of vitamin B 3 (niacin) may also cause Bitot's spots. [5] They can also be caused by Colestyramine , which is a bile acid sequestrant which can reduce the absorption of fat soluble vitamins (Vitamins A, D, E, K)
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Cotton wool spots are commonly caused by changes to the retina secondary to diabetes, hypertension, or blockages to blood vessels to the retina, such as central retinal vein occlusion. [ 5 ] [ 8 ] While at one point believed to have been the result of nerve damage in the retina, interruptions to axoplasmic flow to these nerves may result from ...