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Electrochemotherapy (ECT [1]) is a type of chemotherapy that allows delivery of non-permeant drugs to the cell interior. It is based on the local application of short and intense electric pulses that transiently permeabilize the cell membrane, thus allowing transport of molecules otherwise not permitted by the membrane.
Chronic subcortical electrode implant in a laboratory rat used to deliver electrical stimulation to the brain. Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy and neurotherapy used as a technique in research and clinical neurobiology to stimulate a neuron or neural network in the brain through the direct or indirect excitation ...
This may be due to thermal damage, electroporation of the cell membrane, toxic products from electrochemical reactions at the electrode surface, or over-excitation of the targeted neurons or muscles. Typically FES is concerned with stimulation of neurons and nerves.
The end effect is a "normalization" of a neural network function from its perturbed state. Presumed mechanisms of action for neurostimulation include depolarizing blockade, stochastic normalization of neural firing, axonal blockade, reduction of neural firing keratosis, and suppression of neural network oscillations. [2]
Electrotherapy is the use of electrical energy as a medical treatment. [1] In medicine, the term electrotherapy can apply to a variety of treatments, including the use of electrical devices such as deep brain stimulators for neurological disease. [2]
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Neurotechnology encompasses any method or electronic device which interfaces with the nervous system to monitor or modulate neural activity. [1] [2]Common design goals for neurotechnologies include using neural activity readings to control external devices such as neuroprosthetics, altering neural activity via neuromodulation to repair or normalize function affected by neurological disorders ...
Brainwave entrainment is a colloquialism for 'neural entrainment', [25] which is a term used to denote the way in which the aggregate frequency of oscillations produced by the synchronous electrical activity in ensembles of cortical neurons can adjust to synchronize with the periodic vibration of external stimuli, such as a sustained acoustic ...