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Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re-+ perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
Brain injury, myocardial injury, systemic ischemia/reperfusion response: Usual onset: After resuscitation from a cardiac arrest: Duration: Weeks: Causes: Global ischemia-reperfusion injury: Risk factors: Prolonged cardiac arrest: Differential diagnosis: Systemic inflammatory response syndrome: Management: Hemodynamic stabilization and ...
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. [1] The most common symptom is retrosternal chest pain or discomfort that classically radiates to the left shoulder, arm, or jaw. [1]
Reperfusion therapy is a medical treatment to restore blood flow, either through or around, blocked arteries, typically after a heart attack (myocardial infarction (MI)). Reperfusion therapy includes drugs and surgery. The drugs are thrombolytics and fibrinolytics used in a process called thrombolysis.
reperfusion [7] of previously ischemic tissue that is associated with reperfusion-related diseases, [8] such as myocardial infarction, stroke (cerebral infarction), shock-resuscitation, replantation surgery, frostbite, burns, and organ transplantation. Micrograph of testis showing hemorrhagic infarction. H&E stain.
Contraction band necrosis is a type of uncontrolled cell death unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture. [1] It is a characteristic histologic finding of a recent myocardial infarction (heart attack) that was partially reperfused.
This is known as myocardial infarction. [9] A heart attack can cause arrhythmias, as well as permanent damage to the heart muscle. [25] Coronary ischemia resulting from coronary artery disease also increases the risk of developing heart failure. [10] Most cases of heart failure result from underlying coronary artery disease. [10]
At least 10% of patients with STEMI do not develop myocardial necrosis (as evidenced by a rise in cardiac markers) and subsequent Q waves on EKG after reperfusion therapy. Such a successful restoration of flow to the infarct-related artery during an acute myocardial infarction is known as "aborting" the myocardial infarction.