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Cytarabine is the first of a series of cancer drugs that altered the sugar component of nucleosides. Other cancer drugs modify the base. [13] Cytarabine is often given by continuous intravenous infusion, which follows a biphasic elimination – initial fast clearance rate followed by a slower rate of the analog. [14]
No effective treatment is known for any of these disorders. 80% of these affect the nervous system. [citation needed] Acquired alterations: In this second group the main disorders are infectious diseases, autoimmune illnesses or cancer. In these cases, the changes in glycosylation are the cause of certain biological events.
The manufacturer mentions that there is a correlation between death and treatment (7.5%) [2]. The deaths are because of side effects such as severe infections (26.9%), internal organ bleeding, acute renal failure, bone marrow failure and many other organism failures. This can be within a period of 30 days to 150 days.
Modulating the pyrimidine metabolism pharmacologically has therapeutical uses, and could implement in cancer treatment. [ 10 ] Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid arthritis and psoriatic arthritis , as well as in multiple sclerosis .
The dose-limiting side effects are liver damage, lung disease and immunosuppression. [27] The most common side effects (occurring in >1% of those treated with it) are, in approximately descending order of frequency: [7] [10] [2] [28] [29] [5] [4] diarrhea, respiratory tract infections, hair loss, high blood pressure, rash, nausea, bronchitis, headache, abdominal pain, abnormal liver function ...
The major side effects of tegafur are similar to fluorouracil and include myelosuppression, central neurotoxicity and gastrointestinal toxicity (especially diarrhoea). [3] Gastrointestinal toxicity is the dose-limiting side effect of tegafur. [3] Central neurotoxicity is more common with tegafur than with fluorouracil. [3]
NEIL1 recognizes oxidized pyrimidines, formamidopyrimidines, thymine residues oxidized at the methyl group, and both stereoisomers of thymine glycol. [36] The best substrates for human NEIL1 appear to be the hydantoin lesions, guanidinohydantoin, and spiroiminodihydantoin that are further oxidation products of 8-oxoG .
Pyrimidine analogues are antimetabolites which mimic the structure ... Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA ...