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  2. Haber–Weiss reaction - Wikipedia

    en.wikipedia.org/wiki/Haber–Weiss_reaction

    Haber, Wilstätter and Weiss simply wrote HO 2 or O 2 H, but sometimes HO 2 • or • O 2 H can also be found to stress the radical character of the species. The hydroperoxyl radical is a weak acid and gives rise to the superoxide radical (O 2 •–) when it loses a proton: HO 2 → H + + O 2 – sometimes also written as: HO 2 • → H ...

  3. Lipid peroxidation - Wikipedia

    en.wikipedia.org/wiki/Lipid_peroxidation

    This radical adds O 2 to give hydroperoxyl radical (red). In a propagation step, this hydroperoxyl radical abstracts an H + atom from a new diene, generating a new pentadienyl radical and a hydroperoxide (blue). The chemical reaction of lipid peroxidation consists of three phases: initiation, propagation, and termination. [4]

  4. Hydroxyl radical - Wikipedia

    en.wikipedia.org/wiki/Hydroxyl_radical

    Hydroxyl radicals are also produced during UV-light dissociation of H 2 O 2 (suggested in 1879) and likely in Fenton chemistry, where trace amounts of reduced transition metals catalyze peroxide-mediated oxidations of organic compounds. In organic synthesis hydroxyl radicals are most commonly generated by photolysis of 1-Hydroxy-2(1H ...

  5. Rate-of-living theory - Wikipedia

    en.wikipedia.org/wiki/Rate-of-living_theory

    Mechanistic evidence was provided by Denham Harman's free radical theory of aging, created in the 1950s. This theory stated that organisms age over time due to the accumulation of damage from free radicals in the body. [4] It also showed that metabolic processes, specifically the mitochondria, are prominent producers of free radicals. [4]

  6. Oxidative stress - Wikipedia

    en.wikipedia.org/wiki/Oxidative_stress

    Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]

  7. Mitochondrial theory of ageing - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_theory_of_ageing

    The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]

  8. Thiyl radical - Wikipedia

    en.wikipedia.org/wiki/Thiyl_radical

    The formation of thiyl radicals in vivo primarily occurs through the action of various radicals on the amino acid cysteine incorporated into proteins. The rate of radical formation is highest with the OH · radical (k = 6.8 x 10 9 M −1 s −1) [3] and decreases through the H · radical (k = 6.8 x 10 9 M −1 s −1) [3] down to peroxyl radicals R-CHOO · (k = 4.2 x 10 3 M −1 s −1).

  9. Free-radical addition - Wikipedia

    en.wikipedia.org/wiki/Free-radical_addition

    Chain propagation: A radical reacts with a non-radical to produce a new radical species; Chain termination: Two radicals react with each other to create a non-radical species; In a free-radical addition, there are two chain propagation steps. In one, the adding radical attaches to a multiply-bonded precursor to give a radical with lesser bond ...