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  2. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    PDE5 inhibitors have been used as a second line therapy in severe cases of Raynaud phenomenon when it is related to systemic sclerosis per The European Society for Vascular Medicine guidelines. [3] Sildenafil, the prototypical PDE5 inhibitor, was originally discovered during the search of a novel treatment for angina.

  3. Benign prostatic hyperplasia - Wikipedia

    en.wikipedia.org/wiki/Benign_prostatic_hyperplasia

    [91] [92] Tadalafil, a phosphodiesterase-5 inhibitor, was considered then rejected by NICE in the UK for the treatment of symptoms associated with BPH. [93] In 2011, the U.S. Food and Drug Administration approved tadalafil to treat the signs and symptoms of benign prostatic hyperplasia, and for the treatment of BPH and erectile dysfunction (ED ...

  4. Phosphodiesterase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Phosphodiesterase_inhibitor

    A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this ...

  5. Discovery and development of phosphodiesterase 5 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    Adding PDE5 inhibitors to SSRI drugs (e.g. paroxetine) for the treatment of premature ejaculation could result in better ejaculatory control according to recent studies. [11] Possible mechanism is based on nitric oxide (NO)/cGMP transduction system as a central and peripheral mediator of inhibitory non-adrenergic, non-cholinergic nitrergic ...

  6. Tamsulosin - Wikipedia

    en.wikipedia.org/wiki/Tamsulosin

    Tamsulosin, sold under the brand names including Flomax and Contiflo, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones. [6] [7] [8] The evidence for benefit with a kidney stone is better when the stone is larger. [8] Tamsulosin is taken by mouth. [6]

  7. 4 Common ED Pills: Weighing the Pros & Cons of Each - AOL

    www.aol.com/4-common-ed-pills-weighing-141800609...

    The best ED medication is the one that works for your symptoms and lifestyle. ... With improved blood flow, PDE5 inhibitors make it easier for your privates to become firm and enlarged in response ...