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Certain side effects, like breast enlargement, reduced premenstrual symptoms, and less oily skin/greasy hair, could be beneficial. Side effects often could not be unambiguously attributed to spironolactone due concomitant use of other medications, particularly birth control pills.
Certain side effects, like breast enlargement, reduced premenstrual symptoms, and less oily skin/greasy hair, could be beneficial. Side effects often could not be unambiguously attributed to spironolactone due concomitant use of other medications, particularly birth control pills.
[16] [17] In any case, if one or both of these actions are clinically relevant, they might contribute to the menstrual irregularities and breast side effects of spironolactone. [14] [18] Spironolactone is also an agonist of the pregnane X receptor, [19] and is able to induce the expression of CYP3A4 and P-glycoprotein in the body via this action.
Normal histology of the breast during lactation. Mammoplasia is the normal or spontaneous enlargement of human breasts. [1] Mammoplasia occurs normally during puberty and pregnancy in women, as well as during certain periods of the menstrual cycle. [2] [3] [4] When it occurs in males, it is called gynecomastia and is considered to be ...
Decreased breast size. Dark, thickened skin patches at the back of the neck, on knuckles or elbows and in skinfolds. Increased muscle size. Tiredness. Sleep problems. Headaches. Mood swings ...
Spironolactone stops androgen from binding to receptors, which reduces testosterone and DHT levels and decreases hair loss. Women who are pregnant or trying to get pregnant shouldn’t take ...
The trial was stopped early because the beneficial effect of spironolactone on all-cause death exceeded the prespecified discontinuation requirements. Spironolactone reduced the risk of death by 30% compared to placebo. Additionally, there was a 35% reduction in the risk of hospitalization for worsening heart failure in the spironolactone group.
Women diagnosed with breast cancer before 45 experienced sexual side effects and do not know where to turn for help. Living Beyond Breast cancer advocates for help.