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In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and fatigue. [2] Most people recover in two to four weeks; however, feeling tired may last for months. [2] The liver or spleen may also become swollen, [3] and in less than one percent of cases splenic rupture may occur. [6]
This regimen is currently recommended, particularly for primary HLH in young children, as induction therapy for EBV+ HLH except in patients with the macrophage activation syndrome where pulse methylprednisolone is the preferred treatment. Response rates are somewhat higher in young children than adults and in primary rather than secondary disease.
It is estimated to affect about 1.5 percent of young women yearly. [8] In the United States PID is estimated to affect about one million people yearly. [12] Rates are highest with teenagers and first time mothers. PID causes over 100,000 women to become infertile in the US each year. [27] [42]
HRCTs of TSC patients reveals that about 20% of women have cystic change by age 20 and about 80% of women have cystic changes after age 40. [79] LAM is sometimes revealed by chest CT in patients who present with an apparent primary spontaneous pneumothorax, but more often CT scanning is not ordered (in the United States) until recurrences occur.
Increased age (up to the 70s) is a risk factor for epithelial ovarian cancer because more mutations in cells can accumulate and eventually cause cancer. Those over 80 are at slightly lower risk. [29] Smoking tobacco is associated with a higher risk of mucinous ovarian cancer; after smoking cessation, the risk eventually returns to normal.
The revised five-factor score is associated with five-year mortality from GPA and is based on these criteria: Age greater than 65 years, cardiac symptoms, gastrointestinal involvement, chronic kidney disease, and the absence of ear, nose, and throat symptoms. [7] With corticosteroids and cyclophosphamide, five-year survival is over 80%. [13]
Hydroxycarbamide, also known as hydroxyurea, is an antimetabolite medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. [4] [5] In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks. [4] It is taken by mouth. [4]
Estimates of the percentage of patients with SVT who also have DVT vary between 6% and 53%, and symptomatic pulmonary embolism has been reported in 0% to 10% of patients with SVT. [4] Deep venous system, and may lead to pulmonary embolism. [14] On the breast, there have been occasional cases of associated cancer. [15]