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A refill bottle can contain up to 100 mg/ml of nicotine, [158] which is meant to be diluted before use. [162] Some users, probably due to financial reasons and the willingness to experiment, are opting to make homemade e-liquids. [28] A small percentage of liquids without flavoring is also sold. [163] The flavorings may be natural or artificial ...
A 2016 review found "The nicotine contained in the aerosol from 13 puffs of an e-cigarette in which the nicotine concentration of the liquid is 18 mg per milliliter has been estimated to be similar to the amount in the smoke of a typical tobacco cigarette, which contains approximately 0.5 mg of nicotine." [154]
Nicotine is especially toxic to young children, and a 60 ml bottle of e-liquid with 11 mg/ml nicotine concentration, the average e-liquid bottle in the U.S., [282] is likely to kill a child of age 4 or younger.
A 2015 study found that users vaping non-nicotine e-liquid exhibited signs of dependence. [205] Experienced users tend to take longer puffs which may result in higher nicotine intake. [ 102 ] It is difficult to assess the impact of nicotine dependence from e-cigarette use because of the wide range of e-cigarette products. [ 204 ]
The latest generation of e-cigarettes, "pod products," such as Juul, have the highest nicotine content (50 mg/mL), in protonated salt, rather than the free-base nicotine form found in earlier generations. [15] In June 2015, Juul introduced a pod mod device containing nicotine salt. [16]
The estimated lower dose limit for fatal outcomes is 500–1,000 mg of ingested nicotine for an adult (6.5–13 mg/kg). [27] [29] Nicotine addiction involves drug-reinforced behavior, compulsive use, and relapse following abstinence. [30] Nicotine dependence involves tolerance, sensitization, [31] physical dependence, and psychological ...
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