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The extracellular fluid, in particular the interstitial fluid, constitutes the body's internal environment that bathes all of the cells in the body. The ECF composition is therefore crucial for their normal functions, and is maintained by a number of homeostatic mechanisms involving negative feedback .
The main intravascular fluid in mammals is blood, a complex mixture with elements of a suspension (blood cells), colloid (), and solutes (glucose and ions).The blood represents both the intracellular compartment (the fluid inside the blood cells) and the extracellular compartment (the blood plasma).
Extracellular fluid (1/3 of body water) is fluid contained in areas outside of cells. For a 40-litre body, about 15 litres is extracellular, [9] which amounts to 37.5%. Plasma (1/5 of extracellular fluid). Of this 15 litres of extracellular fluid, plasma volume averages 3 litres, [9] or 20%. Interstitial fluid (4/5 of extracellular fluid)
[1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. [2] The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs.
The total body of water is divided into fluid compartments, [1] between the intracellular fluid compartment (also called space, or volume) and the extracellular fluid (ECF) compartment (space, volume) in a two-to-one ratio: 28 (28–32) liters are inside cells and 14 (14–15) liters are outside cells.
It is the intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins , globulins , and fibrinogen ), [ 2 ] glucose , clotting factors , electrolytes ( Na +
In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
Ground substance is an amorphous gel-like substance in the extracellular space of animals that contains all components of the extracellular matrix (ECM) except for fibrous materials such as collagen and elastin. [1] Ground substance is active in the development, movement, and proliferation of tissues, as well as their metabolism.