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2. Atropine - Wikipedia

   en.wikipedia.org/wiki/Atropine

   Atropine, a tropane alkaloid, is an enantiomeric mixture of d-hyoscyamine and l-hyoscyamine [35], with most of its physiological effects due to l-hyoscyamine, the 3(S)-endo isomer of atropine. Its pharmacological effects are due to binding to muscarinic acetylcholine receptors. It is an antimuscarinic agent.

3. Third-degree atrioventricular block - Wikipedia

   en.wikipedia.org/wiki/Third-degree_atrio...

   The 2005 Joint European Resuscitation and Resuscitation Council (UK) guidelines [17] state that atropine is the first-line treatment especially if there were any adverse signs, namely: 1) heart rate < 40 bpm, 2) systolic blood pressure < 100 mm Hg, 3) signs of heart failure, and 4) ventricular arrhythmias requiring suppression. If these fail to ...

4. Cholinergic crisis - Wikipedia

   en.wikipedia.org/wiki/Cholinergic_crisis

   Some elements of the cholinergic crisis can be reversed with antimuscarinic drugs like atropine or diphenhydramine, but the most dangerous effect — respiratory depression, cannot. [ 6 ] The neuromuscular junction, where the brain communicates with muscles (like the diaphragm , the main breathing muscle), works by acetylcholine activating ...

5. Cholinergic blocking drug - Wikipedia

   en.wikipedia.org/wiki/Cholinergic_blocking_drug

   In the 1850s, atropine was used as antispasmodic in asthma treatment and as morphine antidote for its mydriatic effect. [4] Bezold and Bloebaum showed that atropine blocked the effects of vagal stimulation on the heart in 1867. Subsequently in 1872, Heidenhain found its ability to prevent salivary secretion. [6]

6. Muscarinic antagonist - Wikipedia

   en.wikipedia.org/wiki/Muscarinic_antagonist

   However, scopolamine has greater effects on the central nervous system (CNS) than atropine due to its ability to cross the blood–brain barrier. [4] At higher-than-therapeutic doses, atropine and scopolamine cause CNS depression characterized by amnesia, fatigue, and reduction in rapid eye movement sleep.

7. Rapid sequence induction - Wikipedia

   en.wikipedia.org/wiki/Rapid_sequence_induction

   The dosage is between 1 and 3 μg/kg. It is metabolized by liver. The most significant side effect is respiratory depression. [8] Atropine – The process of intubation can cause massive stimulation to vagus nerve, causing bradycardia (low heart rate). The people who are at increased risk of bradycardia are neonates and children. This does not ...