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These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles. Protease inhibitors that have been developed and are currently used in clinical practice include:
Antiretroviral drugs are used to manage HIV/AIDS.Multiple antiretroviral drugs are often combined into a single pill in order to reduce pill burden.. Some of these combinations are complete single-tablet regimens; the others must be combined with additional pills to make a treatment regimen.
Nirmatrelvir is a SARS-CoV-2 main protease (M pro, 3CL pro, nsp5 protease) inhibitor while ritonavir is an HIV-1 protease inhibitor and strong CYP3A inhibitor. [ 10 ] [ 19 ] Nirmatrelvir is the main active agent in the formulation, while ritonavir, which inhibits HIV-1 protease , is a strong CYP3A inhibitor : it inhibits the metabolization of ...
Ritonavir is a protease inhibitor, though it now mainly serves to boost the potency of other protease inhibitors. [8] [9] It may also be used in combination with other medications to treat hepatitis C and COVID-19. [10] [11] It is taken by mouth. [8]
Protease inhibitor can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease; Protease inhibitor (biology): molecules that ...
Nirmatrelvir is a covalent inhibitor, binding directly to the catalytic cysteine (Cys145) residue of the cysteine protease enzyme. [ 22 ] In the co-packaged medication nirmatrelvir/ritonavir , ritonavir serves to slow the metabolism of nirmatrelvir via cytochrome enzyme inhibition, thereby increasing the circulating concentration of the main ...
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