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The Tet-On Advanced transactivator (also known as rtTA2 S-M2) is an alternative version of Tet-On that shows reduced basal expression, and functions at a 10-fold lower Dox concentration than Tet-Off. In addition, its expression is considered to be more stable in eukaryotic cells due to being human codon optimized and utilizing three minimal ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
Tet methylcytosine dioxygenase 2 (TET2) is a human gene. [5] It resides at chromosome 4q 24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies.
[2] [3] Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. [ 3 ] [ 4 ] [ 5 ] The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.
17684 Ensembl ENSG00000164442 ENSMUSG00000039910 UniProt Q99967 O35740 RefSeq (mRNA) NM_006079 NM_001168388 NM_001168389 NM_010828 RefSeq (protein) NP_001161860 NP_001161861 NP_006070 NP_034958 Location (UCSC) Chr 6: 139.37 – 139.37 Mb Chr 10: 17.6 – 17.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded ...
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LTR retrotransposons have direct long terminal repeats that range from ~100 bp to over 5 kb in size. LTR retrotransposons are further sub-classified into the Ty1-copia-like (Pseudoviridae), Ty3-like (Metaviridae, formally referred to as Gypsy-like, a name that is being considered for retirement [4]), and BEL-Pao-like (Belpaoviridae) groups based on both their degree of sequence similarity and ...