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Half-life is constant over the lifetime of an exponentially decaying quantity, and it is a characteristic unit for the exponential decay equation. The accompanying table shows the reduction of a quantity as a function of the number of half-lives elapsed.
This is the form of the equation that is most commonly used to describe exponential decay. Any one of decay constant, mean lifetime, or half-life is sufficient to characterise the decay. The notation λ for the decay constant is a remnant of the usual notation for an eigenvalue.
When radionuclides are used pharmacologically, for example in radiation therapy, they are eliminated through a combination of radioactive decay and biological excretion.An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula:
the half-life is related to the decay constant as follows: set N = N 0 /2 and t = T 1/2 to obtain / = = This relationship between the half-life and the decay constant shows that highly radioactive substances are quickly spent, while those that radiate weakly endure longer.
In radioactive decay the time constant is related to the decay constant (λ), and it represents both the mean lifetime of a decaying system (such as an atom) before it decays, or the time it takes for all but 36.8% of the atoms to decay. For this reason, the time constant is longer than the half-life, which is the time for only 50% of the atoms ...
There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume
Half-life T 1/2 is defined as the ... the half-life of a radionuclide. Where decay constant λ is related to specific radioactivity a by the following equation:
This value is in the denominator of the decay correcting fraction, so it is the same as multiplying the numerator by its inverse (), which is 2.82. (A simple way to check if you are using the decay correct formula right is to put in the value of the half-life in place of "t".