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Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). [2] Hyperforin may be involved in the pharmacological effects of St. John's wort, [2] specifically in its antidepressant effects. [3] [4] [5]
Hypericum perforatum, commonly known as St John's wort (sometimes perforate St John's wort or common St John's wort), is a flowering plant in the family Hypericaceae.It is a perennial plant that grows up to 1 metre (3 ft 3 in) tall, with many yellow flowers that have clearly visible black glands around their edges, long stamens (male reproductive organs), and three pistils (female reproductive ...
and warns that "Combining St. John's wort with certain antidepressants can lead to a potentially life-threatening increase of serotonin, a brain chemical targeted by antidepressants. St. John's wort can also limit the effectiveness of many prescription medicines." [130]
Some chemicals found in trace amounts in food, as well as some dietary supplements, have been shown to inhibit 5-LOX; these include baicalein, caffeic acid, curcumin, [3] hyperforin and St John's wort. [8] [9] [10]
Hypericaceae is a plant family in the order Malpighiales, comprising six to nine genera and up to 700 species, and commonly known as the St. John's wort family. Members are found throughout the world apart from extremely cold or dry habitats. Hypericum and Triadenum occur in temperate regions but other genera are mostly tropical.
Triadenum fraseri, commonly known as bog St. John's wort, Fraser's St. John's wort, and Fraser's marsh St. John's wort, is a perennial flowering plant in the family Hypericaceae that grows in wetlands of Canada and the northern United States. [2] [3] [4] It is named after John Fraser (1750–1811), a Scottish botanist and widely travelled plant ...
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