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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
213464 Ensembl ENSG00000117222 ENSMUSG00000026439 UniProt Q15291 Q8BX09 RefSeq (mRNA) NM_001193272 NM_001193273 NM_005057 NM_172517 NM_001357486 NM_001357487 RefSeq (protein) NP_001180201 NP_001180202 NP_005048 NP_766105 NP_001344415 NP_001344416 Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.41 – 132.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma-binding ...
5932 225182 Ensembl ENSG00000101773 ENSMUSG00000041238 UniProt Q99708 Q80YR6 RefSeq (mRNA) NM_002894 NM_203291 NM_203292 NM_001081223 NM_001252495 NM_175458 RefSeq (protein) NP_002885 NP_976036 NP_976037 NP_002885.1 NP_976036.1 NP_001074692 NP_001239424 Location (UCSC) Chr 18: 22.8 – 23.03 Mb Chr 18: 11.77 – 11.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma ...
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_002893 NM_009031 RefSeq (protein) NP_001185648 NP_002884 NP_033057 Location (UCSC) Chr X: 16.84 – 16.87 Mb Chr X: 161.54 – 161.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. Function ...
Non-pineal TRb, however, is often diagnosed simultaneous with retinoblastoma. Prognosis of patients with trilateral retinoblastoma is dismal, only a few patients have survived more than 5 years after diagnosis; all survivors were diagnosed with small tumors in a subclinical stage. [ 1 ]
Online video platforms allow users to upload, share videos or live stream their own videos to the Internet. These can either be for the general public to watch, or particular users on a shared network. The most popular video hosting website is YouTube, 2 billion active until October 2020 and the most extensive catalog of online videos. [1]