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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
213464 Ensembl ENSG00000117222 ENSMUSG00000026439 UniProt Q15291 Q8BX09 RefSeq (mRNA) NM_001193272 NM_001193273 NM_005057 NM_172517 NM_001357486 NM_001357487 RefSeq (protein) NP_001180201 NP_001180202 NP_005048 NP_766105 NP_001344415 NP_001344416 Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.41 – 132.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma-binding ...
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
Online database of the historical population of Romania, with a family history wiki using MediaWiki: Geneanet: French genealogical website of more than 3 million members and some digitized archival records Geni.com: Large genealogy website most notable for its work to compile a singular "world family tree" that connects all volunteers.
In non-inherited retinoblastoma, instead two mutations, or "hits", had to take place before a tumor could develop, explaining the later onset. It was later found that carcinogenesis (the development of cancer) depended both on the mutation of proto-oncogenes (genes that stimulate cell proliferation ) and on the inactivation of tumor suppressor ...
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
Non-pineal TRb, however, is often diagnosed simultaneous with retinoblastoma. Prognosis of patients with trilateral retinoblastoma is dismal, only a few patients have survived more than 5 years after diagnosis; all survivors were diagnosed with small tumors in a subclinical stage. [ 1 ]
It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.