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This time is called the half-life, and often denoted by the symbol t 1/2. The half-life can be written in terms of the decay constant, or the mean lifetime, as: / = = (). When this expression is inserted for in the exponential equation above, and ln 2 is absorbed into the base, this equation becomes:
The term "half-life" is almost exclusively used for decay processes that are exponential (such as radioactive decay or the other examples above), or approximately exponential (such as biological half-life discussed below). In a decay process that is not even close to exponential, the half-life will change dramatically while the decay is happening.
The relationship between the elimination rate constant and half-life is given by the following equation: = / Because ln 2 equals 0.693, the half-life is readily calculated from the elimination rate constant.
In principle a half-life, a third-life, or even a (1/√2)-life, could be used in exactly the same way as half-life; but the mean life and half-life t 1/2 have been adopted as standard times associated with exponential decay. Those parameters can be related to the following time-dependent parameters:
The integral solution is described by exponential decay: =, where N 0 is the initial quantity of atoms at time t = 0. Half-life T 1/2 is defined as the length of time for half of a given quantity of radioactive atoms to undergo radioactive decay:
In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t 1 / 2 ) of 24–36 h; this means that a change in the dose will take the best part of a week to ...
The doubling time is a characteristic unit (a natural unit of scale) for the exponential growth equation, and its converse for exponential decay is the half-life. As an example, Canada's net population growth was 2.7 percent in the year 2022, dividing 72 by 2.7 gives an approximate doubling time of about 27 years.
Radioactive isotope table "lists ALL radioactive nuclei with a half-life greater than 1000 years", incorporated in the list above. The NUBASE2020 evaluation of nuclear physics properties F.G. Kondev et al. 2021 Chinese Phys. C 45 030001. The PDF of this article lists the half-lives of all known radioactives nuclides.