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Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987, although references to its use go back to 1795 by Edward Jenner .
Through the analysis of the role of uncertainty in medicine and the clinical equipoise principle, Djulbegovic introduced the concept of "the law of therapeutic discovery." [ 26 ] [ 27 ] This theory predicts a 50-70% success rate in discovering new treatments in randomized clinical trials (RCT) based on the foundational ethical and scientific ...
Equipoise may refer to: Clinical equipoise, or the principle of equipoise, a medical research term; Equilibrioception, the state of being balanced or in equilibrium; Boldenone undecylenate, an anabolic steroid, by the trade name Equipoise; Hydroxyzine, an antihistamine, by trade name Equipoise; Equipoise (Happy Rhodes album), 1993
The Belmont Report is a 1978 report created by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.Its full title is the Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research, Report of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.
The Declaration of Helsinki (DoH, Finnish: Helsingin julistus) is a set of ethical principles regarding human experimentation developed originally in 1964 for the medical community by the World Medical Association (WMA). [1] It is widely regarded as the cornerstone document on human research ethics. [1] [2] [3] [4]
In philosophy, Occam's razor (also spelled Ockham's razor or Ocham's razor; Latin: novacula Occami) is the problem-solving principle that recommends searching for explanations constructed with the smallest possible set of elements. It is also known as the principle of parsimony or the law of parsimony (Latin: lex parsimoniae).
The principle of indifference (also called principle of insufficient reason) is a rule for assigning epistemic probabilities. The principle of indifference states that in the absence of any relevant evidence, agents should distribute their credence (or "degrees of belief") equally among all the possible outcomes under consideration.
This is the principle Lashley referred to as equipotentiality. Extensive regions of the cerebral cortex have the potentiality for mediating specific learning and memory functions. His principle of "mass action" stated that the cerebral cortex acts as one—as a whole—in many types of learning.