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Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987, although references to its use go back to 1795 by Edward Jenner .
Typical exclusion criteria are defined for either ethical reasons (e.g., children, pregnant women, patients with psychological illnesses, patients who are not able or willing to sign informed consent), to overcome practical issues related to the study itself (e.g., not being able to read, when questionnaires are used for assessment of outcomes ...
For another, "collective equipoise" can conflict with a lack of personal equipoise (e.g., a personal belief that an intervention is effective). [31] Finally, Zelen's design , which has been used for some RCTs, randomizes subjects before they provide informed consent, which may be ethical for RCTs of screening and selected therapies, but is ...
Medical ethics tends to be understood narrowly as applied professional ethics; whereas bioethics has a more expansive application, touching upon the philosophy of science and issues of biotechnology. The two fields often overlap, and the distinction is more so a matter of style than professional consensus.
Equipoise may refer to: Clinical equipoise, or the principle of equipoise, a medical research term; Equilibrioception, the state of being balanced or in equilibrium; Boldenone undecylenate, an anabolic steroid, by the trade name Equipoise; Hydroxyzine, an antihistamine, by trade name Equipoise; Equipoise (Happy Rhodes album), 1993
Randomization of treatment in clinical trials pose ethical problems. In some cases, randomization reduces the therapeutic options for both physician and patient, and so randomization requires clinical equipoise regarding the treatments.
The protocol should address the ethical issues and indicate that it is in compliance with the Declaration (Article 14). Studies should be discontinued if the available information indicates that the original considerations are no longer satisfied (Article 17). Information regarding the study should be publicly available (Article 16).
The Beecher Prize, named in honor of Henry K. Beecher, is awarded annually by Harvard Medical School to a medical student who has produced exceptional work in the field of medical ethics. Also, the Henry K. Beecher Award by The Hastings Center was established in 1976 in honour of Henry K. Beecher, who was also its first recipient.