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Metallosis is the medical condition involving deposition and build-up of metal debris in the soft tissues of the body. [1]Metallosis has been known to occur when metallic components in medical implants, specifically joint replacements, abrade against one another. [1]
Macrophages at the implant site fuse to form foreign body giant cells. [6] Following the inflammatory response, granulation tissue form. The end stage of the foreign body reaction is the fibrous capsule formation around the implanted biomaterial. [6] The biocompatibility of the device affects the severity of the foreign body reaction. [7]
Other complications that can occur include risk of rejection from implant-induced coagulation and allergic foreign body response. Depending on the type of implant, the complications may vary. [1] When the site of an implant becomes infected during or after surgery, the surrounding tissue becomes infected by microorganisms. Three main categories ...
Foreign body giant cells are involved in the foreign body reaction, phagocytosis, and subsequent degradation of biomaterials which may lead to failure of the implanted material. [4] When produced, the FBGC's place themselves along the surface of the implantation, and will remain there for as long as the foreign material remains in the body. [1]
Unicompartmental knee arthroplasty (UKA) is a surgical procedure used to relieve arthritis in one of the knee compartments in which the damaged parts of the knee are replaced. UKA surgery may reduce post-operative pain and have a shorter recovery period than a total knee replacement procedure, [ 1 ] [ 2 ] particularly in people over 75 years of ...
This is because the patient's body needs to adapt to the foreign material and integrate the alloplastic implant or graft with its surrounding tissue. [ 5 ] [ 19 ] The surgical technique of alloplasty if completed incorrectly can cause significant and irreversible damage to surrounding nerves by the improper placement of osteotomy.
The current body of evidence suggests if a tourniquet is used in knee replacement surgery, it probably increases the risk of severe side effects and postoperative pain. [30] The evidence did not show any clear benefit on patient function, treatment success or quality of life.
TMJ prostheses became popular with the introduction of Vitek, but evidence that the implants could cause debilitating reactions including pain, malocclusion, and foreign-body giant cell reaction (FBGCR) resulting in degeneration of the surrounding tissue led to a recall by the FDA on 1/7/91. Since Vitek declared bankruptcy in June 1990 and the ...