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The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium. KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). [1]
Basal cells in the basal layer (stratum basale) of the skin are sometimes referred to as basal keratinocytes. [2] Keratinocytes form a barrier against environmental damage by heat , UV radiation , water loss , pathogenic bacteria , fungi , parasites , and viruses .
Transgenic mice over-expressing the transcription factor Gli2 under the K5 promoter in cutaneous keratinocytes develop multiple skin tumours on the ears, tail, trunk and dorsal aspect of the paw, resembling those of basal cell carcinoma (BCC). Unlike Gli1 transgenic mice, Gli2 transgenic mice only developed BCC-like tumors.
14178 Ensembl ENSG00000140285 ENSMUSG00000027208 UniProt P21781 P36363 RefSeq (mRNA) NM_002009 NM_008008 RefSeq (protein) NP_002000 NP_032034 Location (UCSC) Chr 15: 49.42 – 49.49 Mb Chr 2: 125.88 – 125.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene. Function The protein encoded by this gene is ...
The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermal layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss.
IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] follicular dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal lymphocytes. [13]
Interestingly, after a stunning 20-day run of gains, Meta saw its worst week since July, with a drop of 7.2%. The stock fell every day last week and continued to slide today. The stock fell every ...
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [ 5 ] [ 6 ] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins , themselves a family of closely related molecules.