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In contrast, damage to the thalamus can result in coma. Atrophy of the thalamus is an indicator of the start of multiple sclerosis. [70] [71] Thalamic volume loss by atrophy, is also significantly shown in sporadic frontotemporal dementia, noted in the anterior-dorsal thickness. [72]
Dejerine–Roussy syndrome or thalamic pain syndrome is a condition developed after a thalamic stroke, a stroke causing damage to the thalamus. [1] Ischemic strokes and hemorrhagic strokes can cause lesioning in the thalamus.
Vascular thalamic amnesia occurs when the thalamus is affected by Korsakoff's syndrome or damaged by lacunar infarcts or hemorrhages. [1] Another common cause for damage to the thalamus that may contribute to the development of amnesia is a stroke. [ 2 ]
The cause of his amnesia was found to be a thalamic lesion extending to the hypothalamus. Damage to the temporal cortex was also found and thought to be a result of an exploratory surgery. [1] In 1960, when Patient N.A. was 22 years old, a fencing foil went up his nose and injured his brain.
The spinothalamic tract is a nerve tract in the anterolateral system in the spinal cord. [1] This tract is an ascending sensory pathway to the thalamus.From the ventral posterolateral nucleus in the thalamus, sensory information is relayed upward to the somatosensory cortex of the postcentral gyrus.
Severe damage to the medial dorsal nucleus inevitably results in memory deficit. Additionally, autopsies of people who had KS have showed lesions in both the midline and anterior thalamus, and thalamic infarctions. Bilateral infarctions to the thalamus can result in Korsakoff-induced amnesia as well.
Posterior cerebral artery syndrome is a condition whereby the blood supply from the posterior cerebral artery (PCA) is restricted, leading to a reduction of the function of the portions of the brain supplied by that vessel: the occipital lobe, the inferomedial temporal lobe, a large portion of the thalamus, and the upper brainstem and midbrain.
Thalamotomy is a complex procedure performed by specialist neurosurgeons. It is mostly indicated in cases of stroke, damage to third ventricle of brain, brain hemorrhage, accidents leading to head injury, oedema around thalamus, subdural hemorrhage, and cerebrovascular accident. There is also some evidence in thalamocortical dysrhythmia.