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Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.
Orexins – dual OX 1 and OX 2 receptor agonists Orexin-A – approximately equipotent at the OX 1 and OX 2 receptors [2] [3] Orexin-B – approximately 5- to 10-fold selectivity for the OX 2 receptor over the OX 1 receptor [2] [3] AEX-5 – selective OX 1 receptor agonist; also a cathepsin H inhibitor and dopamine reuptake inhibitor [11]
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Toxic: a chemical that has a median lethal concentration (LC 50) in air of more than 200 parts per million (ppm) but not more than 2,000 parts per million by volume of gas or vapor, or more than 2 milligrams per liter but not more than 20 milligrams per liter of mist, fume or dust, when administered by continuous inhalation for 1 hour (or less if death occurs within 1 hour) to albino rats ...
After the start of the competition, the rat achieved first place by performing on the flute while upon the back of the ox. Impressed, the Jade Emperor placed the rat at the beginning of the twelve-year cycle (and the ox second, for being so generous as to allow the rat to play the flute upon the ox's back).
Meanwhile, Ox finds Sheep, who barely escapes, leaving an explosive booby trap behind. Horse is still alive but wounded and emerges from the underground, shocked by Ox's attacks. The headless Snake pursues Rat with a flamethrower, and Rat finally realizes that Snake uses the sound of his movement to follow him.
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the orexin receptors, OX 1 and OX 2. [1]
Kotobuki - A Japanese Chimera with the head of a rat, the ears of a rabbit, the horns of an ox, the comb of a rooster, the beard of a sheep, the neck of a Japanese dragon, the mane of a horse, the back of a wild boar, the shoulders and belly of a South China tiger, the arms of a monkey, the hindquarters of a dog, and the tail of a snake.