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Secondly, it is also vital that the G2/M transition occur unidirectionally, or only once per cell cycle Biological systems are inherently noisy, and small fluctuations in cyclin B1 concentrations near the threshold for the G2/M transition should not cause the cell to switch back and forth between interphase and M-phase states. This is ensured ...
Interphase is the active portion of the cell cycle that includes the G1, S, and G2 phases, where the cell grows, replicates its DNA, and prepares for mitosis, respectively. Interphase was formerly called the " resting phase ," but the cell in interphase is not simply dormant .
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Interphase consists of three main phases: G 1, S, and G 2. G 1 is a time of growth for the cell where specialized cellular functions occur in order to prepare the cell for DNA replication. [16] There are checkpoints during interphase that allow the cell to either advance or halt further development.
At the end of G2, the cell transitions into mitosis, where the nucleus divides. The G2 to M transition is dramatic; there is an all-or-nothing effect, and the transition is irreversible. This is advantageous to the cell because entering mitosis is a critical step in the life cycle of a cell.
BDNF prevents the G2/M transition through its receptor TrkB and their capacity to decrease cyclin B and Cdk1. The mechanism by which neurons undergo apoptosis after the G2/M transition is not yet fully understood, it is known that Cdk1 can activate the pro-apoptotic factor Bad by phosphorylating its Ser128 (Frade, 2000).
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Figure 1: Schematic of the cell cycle. outer ring: I = Interphase, M = Mitosis; inner ring: M = Mitosis, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis; not in ring: G 0 = Gap 0/Resting. Replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated.