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Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Frequency. 1 per 1000 people [8] Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [5] The most common initial symptoms are feeling tired and weak. [4]
6% (< 60 years old), 20% (> 60 years old) [ 4 ] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [ 5 ] Symptoms can vary from none to severe. [ 1 ] Mild deficiency may have few or absent symptoms. [ 1 ]
It has a low affinity for folic acid. Production of the receptor proteins is increased in times of folate deficiency. [78] In addition to a role in intestinal absorption, RFC is expressed in virtually all tissues and is the major route of delivery of folate to cells within the systemic circulation under physiological conditions.
Megavitamin-B6 syndrome, also known as hypervitaminosis B6, vitamin B6 toxicity, and vitamin B6 excess, [ a ] is a medical condition characterized by adverse effects resulting from excessive intake of vitamin B 6. [ 1 ][ 2 ][ 22 ] Primarily affecting the nervous system, this syndrome manifests through symptoms such as peripheral sensory ...
This can result in fatigue, decreased ability to think, lightheadedness, shortness of breath, frequent infections, poor appetite, numbness in the hands and feet, depression, memory loss, confusion, difficulty walking, blurred vision, irreversible nerve damage, and many others. [14]
Neurology. Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim 's disease, [2][3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
Cerebral folate deficiency. Cerebral folate deficiency is a condition in which concentrations of 5-methyltetrahydrofolate are low in the brain as measured in the cerebral spinal fluid despite being normal in the blood. [3] Symptoms typically appear at about 5 to 24 months of age. [3][2] Without treatment there may be poor muscle tone, trouble ...