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  2. Thrombomodulin - Wikipedia

    en.wikipedia.org/wiki/Thrombomodulin

    Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. [ 5 ]

  3. Thrombin - Wikipedia

    en.wikipedia.org/wiki/Thrombin

    Thrombin (Factor IIa) (EC 3.4.21.5, fibrose, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions. [5] [6]

  4. Carboxypeptidase B2 - Wikipedia

    en.wikipedia.org/wiki/Carboxypeptidase_B2

    When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen. [8] [9] Carboxypeptidases are enzymes that hydrolyze C-terminal ...

  5. Protein C - Wikipedia

    en.wikipedia.org/wiki/Protein_C

    This cytokine is conjectured to improve activation of protein C by forming an electrostatic bridge from protein C's Gla domain to the glycosaminoglycan (GAG) domain of thrombomodulin, reducing the Michaelis constant (K M) for their reaction. [16]: 2386 [34]: 29S In addition, Protein C is inhibited by protein C inhibitor. [35]: 369

  6. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    The contact activation (intrinsic) pathway is initiated by activation of the contact activation system, and can be measured by the activated partial thromboplastin time (aPTT) test. [ 48 ] The tissue factor (extrinsic) pathway is initiated by release of tissue factor (a specific cellular lipoprotein), and can be measured by the prothrombin time ...

  7. Hemostasis - Wikipedia

    en.wikipedia.org/wiki/Hemostasis

    Hemostasis is maintained in the body via three mechanisms: Vascular spasm: Vasoconstriction is produced by vascular smooth muscle cells, and is the blood vessel's first response to injury. The smooth muscle cells are controlled by vascular endothelium, which releases intravascular signals to control the contracting properties.

  8. Concerted metalation deprotonation - Wikipedia

    en.wikipedia.org/wiki/Concerted_metalation_de...

    Reaction systems that are less efficient or entirely inactive in the absence of carboxylate acids and bases are likely to occur through a concerted metalation protonation reaction pathway. [15] An example of such a reaction with an sp 3 C–H bond that was reported in 2007 by Keith Fagnou and coworkers is an intramolecular cyclization that uses ...

  9. Thromboplastin - Wikipedia

    en.wikipedia.org/wiki/Thromboplastin

    Thromboplastin (TPL) is derived from cell membranes and is a mixture of both phospholipids and tissue factor, neither of which are enzymes.Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, [1] aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin.