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Losartan should not be taken by people who are diabetic and taking aliskiren. [3] Anemia may occur, due to inhibition of the renin–angiotensin system. [ 17 ] As with other angiotensin receptor blockers, losartan may injure the liver, although this effect appears to be rare. [ 18 ]
If you take one metformin tablet a day, it’s usually recommended that you take it with your evening meal. So, for example, the best time to take metformin 500mg once a day would be after your ...
Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1] [2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1] [2] It is taken by mouth. [1] [2]
The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. [ 3 ]
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A clinical trial done on over 7000 participants showed higher rates of nasopharyngitis in those taking valsartan/hydrochlorothiazide (2.4% versus 1.9% in placebo). [2] [12] A dose-related side effect seen is hypotension, occurring in 0.7% of participants on the highest dose of the medication.
However, they also recommend that patients should not stop taking aliskiren without talking to a healthcare professional. [50] Aliskiren in combination with hydrochlorothiazide was approved by the FDA in 2008 under the tradename Tekturna HCT. [51] [52]
The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used [1] or when resuming the drug after many months off. [2]