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Daflon is an oral micronized purified phlebotonic flavonoid fraction containing 90% diosmin and 10% hesperidin. It is manufactured by Laboratoires Servier and often used to treat or manage disorders of the blood vessels.
Diosmin is a dietary supplement used to aid treatment of hemorrhoids and venous diseases, i.e., chronic venous insufficiency including spider and varicose veins, leg swelling , stasis dermatitis and venous ulcers. [1] The mechanism of action of Diosmin and other phlebotonics is undefined, [1] and clinical evidence of benefit is limited. [1]
Mean flavonoid intake in mg/d per country, the pie charts show the relative contribution of different types of flavonoids. [16] Food composition data for flavonoids were provided by the USDA database on flavonoids. [11] In the United States NHANES survey, mean flavonoid intake was 190 mg per day in adults, with flavan-3-ols as the main ...
Hesperidin is a flavanone glycoside found in citrus fruits. Its aglycone is hesperetin. Its name is derived from the word "hesperidium", for fruit produced by citrus trees. Hesperidin was first isolated in 1828 by French chemist M. Lebreton from the white inner layer of citrus peels (mesocarp, albedo). [2] [3]
Typical doses are in the order of 1,000 mg/day. [5] Effects of hydroxyethylrutosides against adriamycin-induced toxicity have been investigated in rats. [6] References
Diosmin/hesperidin and other flavonoids. Anti-inflammatory medication such as ibuprofen or aspirin can be used as part of treatment for superficial thrombophlebitis along with graduated compression hosiery – but there is a risk of intestinal bleeding. In extensive superficial thrombophlebitis, consideration should be given to anti-coagulation ...