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CIPN afflicts between 30% and 40% of patients undergoing chemotherapy. Antineoplastic agents in chemotherapy are designed to eliminate rapidly dividing cancer cells, but they can also damage healthy structures, including the peripheral nervous system. [1] CIPN involves various symptoms such as tingling, pain, and numbness in the hands and feet. [2]
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Those with femoral nerve dysfunction may present problems of difficulties in movement and a loss of sensation. [medical citation needed] The patient, in terms of motor skills, may have problems such as quadriceps wasting, loss of knee extension and a lesser extent of hip flexion given the femoral nerve involvement of the iliacus and pectineus muscles. [3]
Chemotherapy-induced peripheral neuropathy is a progressive, enduring and often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs caused by some chemotherapy agents.
Pain, numbness, or weakness in the arms or legs [1] Complications: Loss of bladder control, loss of bowel control, sexual dysfunction [1] Usual onset: Gradual [1] Types: Cervical, thoracic, lumbar [2] Causes: Osteoarthritis, rheumatoid arthritis, spinal tumors, trauma, Paget's disease of the bone, scoliosis, spondylolisthesis, achondroplasia [3 ...
Innervation of lateral cutaneous nerve of the thigh (shaded area) on the right leg. Specialty: Neurology: Symptoms: Pain, dysthesias, paresthesias, and hyperesthesia on the anterolateral thigh [2] Causes: Anything that compresses the lateral femoral cutaneous nerve, such as tight fitting clothes at the waist and injuries. [3] Risk factors
For example, the Mayo Clinic says, you might see: Blind spots, which might be outlined with geometric designs. Shimmering stars or spots. Zigzag lines that slowly float across your vision. Flashes ...
As the pain subsides, weakness usually appears. In addition, chronicle progressive weakness of one leg suggests a tumor of the spinal cord of the lumbar plexus. Fever is often the first symptom of lumbar plexus paralysis, followed by pain in one or both legs. The pain has an abrupt onset and may occur in a femoral or sciatic distribution.