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Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. [3] In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes .
All subtypes except acute promyelocytic leukemia are usually given induction chemotherapy with cytarabine and an anthracycline such as daunorubicin or idarubicin. [60] This induction chemotherapy regimen is known as " 7+3 " (or "3+7"), because the cytarabine is given as a continuous IV infusion for seven consecutive days while the anthracycline ...
Myeloblast with an Auer rod (to the left of the nucleus).. Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, high-grade myelodysplastic syndromes and myeloproliferative disorders.
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 June 2024. Abnormal blood cells in hypergranular APML A faggot cell (bottom left of the central cell cluster) with a prominent collection of Auer rods from a patient with acute promyelocytic leukemia. Faggot cells are cells normally found in the hypergranular form of acute promyelocytic leukemia (FAB ...
Tretinoin is used to induce remission in people with acute promyelocytic leukemia (APL) who have a mutation (the t(15;17) translocation that gives rise to the PML::RARα fusion gene). It is not used for maintenance therapy. [5] [25] [26] Tretinoin is not effective for the treatment of non-APL forms of Acute Myeloid Leukemia [27] or other forms ...
Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in people with acute promyelocytic leukemia (APML) and first thought to be specifically associated with all-trans retinoic acid (ATRA) (also known as tretinoin) treatment. [1]
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