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Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
[26] [27] [28] The most common adverse effects in Phase III trials were dizziness (25%), drowsiness (8%) and disorientation (4%); 12% of subjects stopped taking the drug because of the side effects. No investigations regarding the potential for dependence are available, but such a potential is unlikely considering the pharmacological properties ...
THC and its 11-OH-THC and THC-COOH metabolites can be detected and quantified in blood, urine, hair, oral fluid or sweat using a combination of immunoassay and chromatographic techniques as part of a drug use testing program or in a forensic investigation. [57] [58] [59] There is ongoing research to create devices capable of detecting THC in ...
Tetrahydrocannabiphorol (THCP) is a potent phytocannabinoid, a CB 1 and CB 2 receptor agonist which was known as a synthetic homologue of tetrahydrocannabinol (THC), [1] but for the first time in 2019 was isolated as a natural product in trace amounts from Cannabis sativa.
THC-O-acetate (THC acetate ester, O-acetyl-THC, THC-O, AcO-THC) is the acetate ester of THC. The term THC-O-acetate and its variations are commonly used for two types of the substance, dependent on which cannabinoid it is synthesized from. The difference between Δ 8-THC and Δ 9-THC is bond placement on the cyclohexene ring. [1]
The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Δ 9-Tetrahydrocannabutol (tetrahydrocannabinol-C4, THC-C4, Δ 9-THCB, (C4)-Δ 9-THC, butyl-THC) is a phytocannabinoid found in cannabis that is a homologue of tetrahydrocannabinol (THC), the main active component of Cannabis. [1] Structurally, they are only different by the pentyl side chain being replaced by a butyl side chain.