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Effect of class III antiarrhythmic agent on cardiac action potential. Potassium channel blockers used in the treatment of cardiac arrhythmia are classified as class III antiarrhythmic agents. Atrial cardiomyocytes contain a specific subset of potassium ion channels which are absent in the ventricles. [1]
The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na +) channel. Class II agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K +) efflux. Class IV agents affect calcium channels and ...
Class Ic antiarrhythmic agents markedly depress the phase 0 depolarization (decreasing V max). They decrease conductivity, but have a minimal effect on the action potential duration. Of the sodium channel blocking antiarrhythmic agents (the class I antiarrhythmic agents), the class Ic agents have the most potent sodium channel blocking effects.
Dofetilide is a class III antiarrhythmic agent. [2] It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 μg of dofetilide. It is not available in Europe [3] or Australia. [4]
[13] [14] Inhibition of the Na v 1.5 channel is specifically involved in its antiarrhythmic effects as a class I antiarrhythmic agent. [15] Quinidine also blocks certain voltage-gated potassium channels (e.g., K v 1.4 , K v 4.2 , hERG , among others), [ 16 ] [ 17 ] acts as an antimuscarinic and alpha-1 blocker , [ 18 ] and is an antimalarial ...
Cross-reactivity, in a general sense, is the reactivity of an observed agent which initiates reactions outside the main reaction expected.This has implications for any kind of test or assay, including diagnostic tests in medicine, and can be a cause of false positives.
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is a sodium channel blocker of cardiomyocytes; thus it is classified by the Vaughan Williams classification system as class Ia. In addition to blocking the I Na current, it inhibits the I Kr rectifier K+ current. [1]
In computing, reactive programming is a declarative programming paradigm concerned with data streams and the propagation of change. With this paradigm, it is possible to express static (e.g., arrays) or dynamic (e.g., event emitters) data streams with ease, and also communicate that an inferred dependency within the associated execution model exists, which facilitates the automatic propagation ...