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Medications that kill rapidly dividing cells or blood cells can reduce the number of platelets in the blood, which can result in bruises and bleeding. Extremely low platelet counts may be temporarily boosted through platelet transfusions and new drugs to increase platelet counts during chemotherapy are being developed.
Iatrogenic causes of pancytopenia include chemotherapy for malignancies if the drug or drugs used cause bone marrow suppression. Rarely, drugs (antibiotics, blood pressure medication, heart medication) can cause pancytopenia. For example, the antibiotic chloramphenicol can cause pancytopenia in some individuals. [1]
HDC aims to increase drug concentrations within the tumor microenvironment by using dosages. This increased dosage helps drugs penetrate into the tumor [12] overcoming obstacles like vasculature and interstitial pressure. The improved availability of drugs allows for distribution throughout the tumor mass reaching resistant cancer cells that ...
They can include low blood cell counts, vomiting, loss of appetite, diarrhea, hair loss, and fever. [2] Other severe side effects include allergic reactions and low blood pressure. [2] [4] Use during pregnancy will likely harm the fetus. [2] Etoposide is in the topoisomerase inhibitor family of medication. [2] It is believed to work by damaging ...
The symptoms of TACO can include shortness of breath , low blood oxygen levels , leg swelling (peripheral edema), high blood pressure (hypertension), and a high heart rate (tachycardia). [ 3 ] It can occur due to a rapid transfusion of a large volume of blood but can also occur during a single red blood cell transfusion (about 15% of cases). [ 2 ]
Pressure on the kidney or ureter from a tumor outside the kidney can cause extreme flank pain. [7] Local recurrence of cancer after the removal of a kidney can cause pain in the lumbar back, or L1 or L2 spinal nerve pain in the groin or upper thigh, accompanied by weakness and numbness of the iliopsoas muscle, exacerbated by activity. [4]
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