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Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. [1] Early on, there may be no symptoms. [1] Gradually joint pain may develop, which may limit the person's ability to move. [1] Complications may include collapse of the bone or nearby joint surface. [1]
Pain in the affected area [1] [2] Muscle spasm in the affected area [1] Numbness and tingling in an arm or leg [1] [2] Paleness [1] [2] of the skin of the arm or leg; Muscle weakness of an arm or leg, [1] [2] possibly to the grade of paralysis [2] Later symptoms are closely related to infarction of the tissue supplied by the occluded artery:
Limb: Limb infarction is an infarction of an arm or leg. Causes include arterial embolisms and skeletal muscle infarction as a rare complication of long standing, poorly controlled diabetes mellitus. [12] A major presentation is painful thigh or leg swelling. [12] Bone: Infarction of bone results in avascular necrosis.
[1] [5] Abrupt onset of pain at the back or neck marks the location of ischaemia or hemorrhage at the beginning, which radiates as the damage intensifies. [ 9 ] [ 10 ] Temporary paresis in limbs may occur days before the onset of spinal ischaemic stroke, though the relationship remains unclear.
Bone pain originates from both the periosteum and the bone marrow which relay nociceptive signals to the brain creating the sensation of pain. Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated sensory neurons. In combination, they can provide an initial burst of pain, initiated by the faster myelinated ...
The commonest symptom of arterial occlusion is intermittent claudication, which consists of a painful, aching sensation in the affected muscle. [3] This is often provoked with physical activity and relieved with rest. Pain and muscle aching may build up with walking, and accelerate with light jogging or walking uphill.
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Anterior spinal artery syndrome is the most common form of spinal cord infarction. [1] The anterior spinal cord is at increased risk for infarction because it is supplied by the single anterior spinal artery and has little collateral circulation, unlike the posterior spinal cord which is supplied by two posterior spinal arteries.