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Irradiation is the process by which an object is exposed to radiation. An irradiator is a device used to expose an object to radiation, notably gamma radiation , for a variety of purposes. [ 1 ]
Blood irradiation therapy is an alternative medical procedure in which the blood is exposed to low-level light (often laser light) for therapeutic reasons. [1] The practice was originally developed in the United States, [1] but most recent research on it has been conducted in Germany (by UV lamps) and in Russia (in all variants).
Universal leukoreduction is currently not practiced in all countries. [citation needed]As of 2008, most developed nations have adopted universal leukoreduction of transfusions (defined as the routine application of this blood-processing step to all units of whole blood, red blood cells, and platelets prior to storage) with the notable exception of the United States. [8]
Therefore, such patients may be issued irradiated blood components, including irradiated red blood cells. [39] [40] X-ray or gamma sources are usually used for irradiation. [40] When blood components are irradiated, the DNA is destroyed in any remaining white blood cells (leucocytes), which stops the leucocytes from being able to proliferate ...
A dose of under 100 rad will typically produce no immediate symptoms other than blood changes. A dose of 100 to 200 rad delivered to the entire body in less than a day may cause acute radiation syndrome (ARS), but is usually not fatal. Doses of 200 to 1,000 rad delivered in a few hours will cause serious illness, with poor prognosis at the ...
Prevention includes gamma irradiation of the lymphocyte-containing blood components such as red blood cells, platelets and granulocytes. Irradiated blood components should be issued in the following situations: [7] Intrauterine transfusions; Prematurity, low birthweight, or erythroblastosis fetalis in newborns; Congenital immunodeficiencies
In most countries, immunohematology and transfusion medicine specialists provide expert opinion on massive transfusions, difficult/incompatible transfusions and rational use of specialised blood product therapy like irradiated blood/leukodepleted/washed blood products.
Radiation necrosis is the death of healthy tissue near the irradiated site. It is a type of coagulative necrosis that occurs because the radiation directly or indirectly damages blood vessels in the area, which reduces the blood supply to the remaining healthy tissue, causing it to die by ischemia, similar to what happens in an ischemic stroke ...