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High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. [ 1 ] History and name
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The group was formed through the purchase of 51% of Kia by Hyundai Motor Company in 1998. As of 2011, Hyundai owns 33.7% [5] of Kia Motors.. On 22 May 2022, the Hyundai Motor Group announced the company would invest an additional $5 billion in the United States by the year 2025.
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HMGB1 has to interact with p53. [15] [16]HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.
HMGN1 and HMGN2 (initially designated HMG-14 and HMG-17 respectively) were discovered by E.W. Johns research group in the early 1970s. [1] HMGN3, HMGN4, and HMGN5 were discovered later and are less abundant. HMGNs are nucleosome binding proteins that help in transcription, replication, recombination, and DNA repair.
HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity. [1]HMG-box domains are found in some high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin. [3]
15364 Ensembl ENSG00000149948 ENSMUSG00000056758 UniProt P52926 P52927 RefSeq (mRNA) NM_003484 NM_001015886 NM_001300918 NM_001300919 NM_003483 NM_001330190 NM_010441 NM_001347170 RefSeq (protein) NP_001287847 NP_001287848 NP_001317119 NP_003474 NP_003475 NP_001334099 NP_034571 Location (UCSC) Chr 12: 65.82 – 65.97 Mb Chr 10: 120.2 – 120.31 Mb PubMed search Wikidata View/Edit Human View ...