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Higher doses also cause vasoconstriction that further increases blood pressure. [16] [17] While some effects result from stimulation of dopamine receptors, the prominent cardiovascular effects result from dopamine acting at α 1, β 1, and β 2 adrenergic receptors. [18] [19]
Other serious side effects are hallucinations, peripheral edema, gastrointestinal ulcers, pulmonary fibrosis and psychosis. [1] [16] Dopamine agonists have been linked to cardiac problems, with side effects such as hypotension, myocardial infarction, congestive heart failure, cardiac fibrosis, pericardial effusion and tachycardia. [1]
More serious side effects include depression, low blood pressure with standing, sudden onset of sleepiness, psychosis, and increased risk-taking behavior. [6] [10] Carbidopa prevents the breakdown of levodopa outside the brain. [10] In the brain, levodopa is broken down into dopamine, its active form. [10]
Side effects of dopamine include negative effects on kidney function and irregular heartbeats. [85] The LD 50 , or lethal dose which is expected to prove fatal in 50% of the population, has been found to be: 59 mg/kg (mouse; administered intravenously ); 95 mg/kg (mouse; administered intraperitoneally ); 163 mg/kg (rat; administered ...
Sometimes, dosage rather than the drug itself results in side effects. Instead of changing your medication, your healthcare provider might adjust your dosage to reduce your risk of experiencing ...
Recent research has found that high-dose prescription amphetamines, often used to treat ADHD, are linked to a seriously heightened risk of psychosis. ... of potential side effects to taking ...
After long-term use of dopamine agonists, a withdrawal syndrome may occur during dose reduction or discontinuation with the following possible side effects: anxiety, panic attacks, dysphoria, depression, agitation, irritability, suicidal ideation, fatigue, orthostatic hypotension, nausea, vomiting, diaphoresis, generalized pain, and drug cravings.
They have largely been replaced by drugs with fewer side effects. SSRIs (selective serotonin reuptake inhibitors), which debuted in the 1980s, work on serotonin.