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  2. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruit–drug_interactions

    Acetaminophen (also known as paracetamol, brand name Tylenol) concentrations increase in the blood of mice when they consume white and pink grapefruit juice, with the white juice acting faster. [64] "The bioavailability of paracetamol was significantly reduced following multiple GFJ administration" in mice and rats.

  3. List of SJS-inducing substances - Wikipedia

    en.wikipedia.org/wiki/List_of_SJS-inducing...

    Acetaminophen, Panadol, Tylenol Penicillins [5] Phenytoin [5] Rivoraxaban [17] Xarelto: Sitagliptin [citation needed] Sulfonamides [2] Tetracycline [2 This page was ...

  4. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Compared to warfarin it has fewer interactions with other medications. [13] It is a direct factor Xa inhibitor. [9] In 2007, Pfizer and Bristol-Myers Squibb began the development of apixaban as an anticoagulant. [14] Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012.

  5. Here's how Tylenol holds up against other common pain relievers

    www.aol.com/heres-tylenol-holds-against-other...

    Tylenol can be used to treat a few different conditions, such as: mild to moderate pain, fever, headaches, muscle aches, toothaches, backaches, colds, and discomfort from a vaccine, says Walia.

  6. Acetaminophen: 4 Things to Know About This Common Over ... - AOL

    www.aol.com/news/2014-01-21-acetaminophen-4...

    For reference, a single tablet of Extra Strength Tylenol contains 500 mg of acetaminophen -- which means just eight tablets would hit the safety threshold. In addition, consuming 1,000 mg (two ...

  7. Paracetamol - Wikipedia

    en.wikipedia.org/wiki/Paracetamol

    Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.

  8. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

    www.aol.com/cialis-side-effects-expect-avoid...

    Cialis can interact with some oral antifungal medications, like itraconazole or ketoconazole, used to treat ringworm, dandruff, or fungal nail infections. These medications, which inhibit the ...

  9. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...