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A theorem of Ravindra Bapat, generalizing Sperner's lemma, [5]: chapter 16, pp. 257–261 implies the KKM lemma extends to connector-free coverings (he proved his theorem for =). The connector-free variant also has a permutation variant, so that both these generalizations can be used simultaneously.
Central pattern generators (CPGs) are self-organizing biological neural circuits [1] [2] that produce rhythmic outputs in the absence of rhythmic input. [3] [4] [5] They are the source of the tightly-coupled patterns of neural activity that drive rhythmic and stereotyped motor behaviors like walking, swimming, breathing, or chewing.
CpG islands (or CG islands) are regions with a high frequency of CpG sites. Though objective definitions for CpG islands are limited, the usual formal definition is a region with at least 200 bp , a GC percentage greater than 50%, and an observed-to-expected CpG ratio greater than 60%.
Template usage notes. This template should only be used on pages that are formal Wikipedia guidelines. For advice that is not a Wikipedia guideline, use the {} or one of its variants, instead. Please do not apply this template to any page without first advertising your proposal to other editors via a request for comments, as described below.
Plates vi & vii of the Edwin Smith Papyrus (around the 17th century BC), among the earliest medical guidelines. A medical guideline (also called a clinical guideline, standard treatment guideline, or clinical practice guideline) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare.
How methylation of CpG sites followed by spontaneous deamination leads to a lack of CpG sites in methylated DNA. As a result residual CpG islands are created in areas where methylation is rare, and CpG sites stick. CG suppression is a term for the phenomenon that CG dinucleotides are very uncommon in most portions of vertebrate genomes.
A standard operating procedure (SOP) is a set of step-by-step instructions compiled by an organization to help workers carry out routine operations. [1] SOPs aim to achieve efficiency, quality output, and uniformity of performance, while reducing miscommunication and failure to comply with industry regulations.
CpG motifs are considered pathogen-associated molecular patterns due to their abundance in microbial genomes but their rarity in vertebrate genomes. [2] The CpG PAMP is recognized by the pattern recognition receptor ( PRR ) Toll-Like Receptor 9 ( TLR9 ), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs ...